Augmentin - 1 gr 14 Tablets

Augmentin is indicated for the treatment of the following infections in adults and children:

*Dental infections (eg periodontitis, maxillary sinusitis, severe dental abscesses with spreading cellulitis) — for tablets 500 mg / 125 mg or 875 mg/ 125 mg;

*Acute bacterial sinusitis *Acute otitis media *Exacerbations of chronic bronchitis *Community-acquired pneumonia *Cystitis *Pyelonephritis *Infections of the skin and soft tissues, in particular phlegmon, *animal bites, severe dental abscess with spreading phlegmon. *Bone and joint infections, in particular osteomyelitis *Official guidelines for the rational use of antibacterial agents should be taken into account.

Trade name: Augmentin

Augmentin

Composition: each tablet contains:

amoxicillin 875 mg clavulanic acid 125mg

Auxiliary components: magnesium stearate

14.5 mg, sodium carboxymethyl starch 29 mg, colloidal silicon dioxide — 10 mg, microcrystalline cellulose — 243.16 mg.

Properties: Amoxicillin is a semi-synthetic penicillin

(beta-lactam antibiotic) that inhibits one or more enzymes (known as penicillin-binding proteins) in the biosynthesis of bacterial peptidoglycan, which is the unifying structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to a thinning of the cell wall, which subsequently leads to lysis and cell death. Amoxicillin is destroyed by the action of lactamases produced by resistant bacteria, and therefore the spectrum of activity of amoxicillin itself does not include microorganisms that produce these enzymes.

Clavulanic acid is a lactamase inhibitor structurally related to penicillins. Clavulanic acid blocks the action of certain lactamase enzymes, thereby preventing the inactivation of amoxicillin. Clavulanic acid alone does not show a clinically significant antibacterial effect.

Indications : Augmentin is indicated for the treatment of the following infections in adults and children:

Dental infections (eg periodontitis, maxillary

sinusitis, severe dental abscesses with spreading cellulitis) — for tablets 500 mg / 125 mg or 875 mg / 125 mg;

Acute bacterial sinusitis

Acute otitis media

Exacerbations of chronic bronchitis

Community-acquired pneumonia

Cystitis

Pyelonephritis

Skin and soft tissue infections, in particular phlegmon, animal bites, severe dental abscess with spreading phlegmon.

Bone and joint infections, particularly osteomyelitis

Official guidelines for the rational use of antibacterial agents should be taken into account.

Method of administration and dosage : For optimal absorption and to reduce possible side effects from the digestive system, Augmentin@ is recommended to be taken at the beginning of a meal.

The dosage regimen is set individually, depending on the severity of the course and localization of the infection, the sensitivity of the pathogen.

Augmentin tablets should not be taken by children under 12 years of age.

Recommended dose for adults and children over 12 years of age: Tablets 875 mg + 125 mg should be used only in patients with CC> 30 ml / min, and no dosage adjustment is required.

The recommended dose is one tablet every 12 hours.

The minimum course of antibiotic therapy is 5 days.

Treatment should not continue for more than 14 days without revising the clinical situati

Contraindications : impaired renal function (CC s30 ml / min) — (for tablets 875 mg / 125 mg), hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, betalactam antibiotics (for example, penicillins, cephalosporins) in anamnesis; previous episodes of jaundice or impaired liver function when using a combination of amoxicillin with clavulanic acid in history.

Precautionary measures : Before starting treatment with Augmentin@, it is necessary to collect a detailed history of previous hypersensitivity reactions to penicillins, cephalosporins or other substances that cause an allergic reaction in the patient.

Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. In the event of an allergic reaction, it is necessary to discontinue treatment with Augmentin@ and begin an appropriate alternative therapy.

Side effects : Infectious and parasitic diseases: often — candidiasis of the skin and mucous membranes.

From the digestive tract : — adults: very often — diarrhea; often — nausea, vomiting; — children: often — diarrhea, nausea, vomiting;

Adverse events from the liver are observed mainly in men and elderly patients and may be associated with long-term therapy. These adverse events are very rare in children.

Storage method : In a cool dry place

Packaging : Cardboard box holds 2 blisters of 7 tablets