Augmentin 457 mg / 5 ml powder for suspension preparation 70 ml

Augmentin is indicated for the treatment of the following infections in adults and children:

* Acute bacterial sinusitis

* Acute otitis media

* Exacerbations of chronic bronchitis

* Community-acquired pneumonia

* Cystitis

* Pyelonephritis

* Skin and soft tissue infections, in particular, phlegmon, animal bites, severe dental abscess with spreading phlegmon.

* Bone and joint infections, in particular osteomyelitis

Trade name: Augmentin

Augmentin

Composition : Each 5 ml of the finished suspension contains 400 mg of amoxicillin and 57 mg of clavulanic acid.

Auxiliary components : xanthan gum — 12.5 mg, aspartame — 12.5 mg, succinic acid — 0.84 mg, colloidal silicon dioxide — 25 mg, hypromellose — 79.65 mg, strawberry flavor 1 — 15 mg, silicon dioxide — up to 900 mg.

Properties : Amoxicillin is a semi-synthetic penicillin (betalactam antibiotic) that inhibits one or more enzymes (known as penicillin-binding proteins) in the biosynthesis of bacterial peptidoglyc which is the unifying structural component the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to a thinning of the cell wall, which subsequently leads to lysis and cell death. Amoxicillin is destroyed by the action of lactamases produced by resistant bacteria, and therefore the spectrum of activity of amoxicillin itself does not include microorganisms that produce these enzymes.

Clavulanic acid is a lactamase inhibitor structurally related to penicillins. Clavulanic acid blocks the action of certain lactamase enzymes, thereby preventing the inactivation of amoxicillin. Clavulanic acid alone does not show a clinically significant antibacterial effect.

Indications: Augmentin is indicated for the treatment of the following infections in adults and children:

Acute bacterial sinusitis Acute otitis media Exacerbations of chronic bronchitis Community-acquired pneumonia Cystitise Pyelonephritis

Infections of the skin and soft tissues, in particular phlegmon, animal bites, severe dental abscess with spreading phlegmon. Bone and joint infections, in particular osteomyelitis Official guidelines for the rational use of antibacterial agents should be taken into account.

Method of administration and dosage: For optimal absorption and to reduce possible side effects from the digestive system, Augmentin@ is recommended to be taken at the beginning of a meal.

The dosage regimen is set individually, depending on the severity of the course and localization of the infection, the sensitivity o the pathogen.

Augmentin tablets should not be taken by children under 12 years of age.

The recommended dose for children over 2-6 years old with a mother of the body (13-21kg) is:

2.5 ml of suspension 2 times a day

Or the highest dose of 5.0 ml 2 times a day

For children 7-12 years old with a body weight (22-40kg) is:

5.0 ml of suspension 2 times a day or the highest dose of 10.0 ml of suspension 2 times a day

The minimum course of antibiotic therapy is 5 days.

Treatment should not continue for more than 14 days without revising the clinical situatio

Contraindications : -Hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, beta-lactam antibiotics (for example, penicillins, cephalosporins) in history;

previous episodes of jaundice or abnormal liver function when using a combination of amoxicillin with clavulanic acid in history;

children up to 2 months of age (for powder for preparation of suspension for oral administration 400 mg / 57 mg in 5 ml);

impaired renal function (CC less than 30 ml / min) — for powder for preparation of a suspension for oral administration of 400 mg / 57 mg in 5 ml;

phenylketonuria.

With care: abnormal liver function.

Precautionary measures: Before starting treatment with Augmentin is necessary to collect a detailed history of previous hypersensitivity reactions to penicillins, cephalosporins or other substances that cause an allergic reaction in the patient.

Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. In the event of an allergic reaction, it is necessary to discontinue treatment with Augmentin@ and begin an appropriate alternative therapy.

Side effects: Infectious and parasitic diseases: often candidiasis of the skin and mucous membranes.

From the digestive tract: adults: very often — diarrhea; often — nausea, vomiting; children: often — diarrhea, nausea, vomiting; Adverse events from the liver are observed mainly in men and elderly patients and may be associated with long-term therapy. These adverse events are very rare in children.

Storage method : In a cool dry place at a temperature not exceeding 25 degrees

The prepared suspension should be stored in a refrigerator at 2 0 to 8 0 C for 7 days.

Suspension preparation instructions: approximately 64 ml of water should be added to the vial with the powder, then close the vial with the lid and shake until the powder is completely diluted, let the vial stand for 5 minutes to ensure complete dilution.

Packaging: Glass bottle 70 ml, paper instruction.