Flixonase - Nasal Spray 50 mcg /120 Doses

Treatments for perennial and seasonal allergic rhinitis, including hay fever:

— pain, feeling of pressure in the area of the paranasal sinuses; — nasal congestion, sneezing, itching in the nose; — lacrimation.

Tradename:

Flixonase Flixonase

Composition and form of release: Dosed nasal spray in the form of an opaque suspension of white color, free from foreign particles. The bottle contains 120 doses.

Each dose contains 50 mcg of micronized fluticasone propionate.

Pharmachologic effect:

Intranasal glucocorticosteroid. It has a pronounced anti-inflammatory effect. With intranasal administration, there is no systemic effect, practically does not inhibit the hypothalamic-pituitary-adrenal system.

The anti-inflammatory effect of fluticasone propionate is realized as a result of its interaction with glucocorticoid receptors. Fluticasone propionate reduces the production of inflammatory mediators and a number of biologically active substances (including histamine, prostaglandins, leukotrienes, cytokines) during the early and late phases of an allergic reaction. It has a fast anti-

inflammatory effect on the nasal mucosa. Antiallergic effect appears within 2-4 hours after the first application. Reduces sneezing, itchy nose, rhinorrhea, nasal congestion, sinus discomfort, and pressure around the nose and eyes. It also relieves eye symptoms associated with allergic rhinitis.

Fluticasone propionate improves the quality of life of patients, including physical and social activity.

Indications: Treatments for perennial and seasonal allergic rhinitis, including hay fever:

pain, feeling of pressure in the area of the paranasal sinuses; nasal congestion, sneezing, itching in the nose;

Contraindications: Hypersensitivity to fluticasone propionate

and other components of the drug;

Children under 4 years old; Recently suffered a nose injury or surgery in the nasal cavity.

Carefully:

Before using the drug, the patient should consult a doctor in the following cases:

taking medications for the treatment of HIV infection, such as ritonavir; taking GCS for the treatment of bronchial asthma, allergies, skin rashes;

Taking medications to treat fungal infections such as ketoconazole

taking other powerful inhibitors of the isoenzyme CYP3A, for example, itraconazole; if you have glaucoma or cataracts.

Use with caution if you have a nasal or sinus infection. It should be borne in mind that infectious diseases of the nose require appropriate treatment, but are not a contraindication to the use of Flixonase nasal spray.

Application during pregnancy and lactation:

Before using the drug Fliksonase during pregnancy and lactation, you should consult your doctor.

For pregnant and lactating women, Fliksonase can be prescribed only if the expected benefit to the patient outweighs any possible risk to the fetus or child.

Side effects: Determination of the frequency of side effects: very often (? 1/10), often (? 1/100 and < 1/10), infrequently (? 1/1000 and <1/100), rarely (? 1/10 000 and / 1000), very rare (<1/10 000, including isolated cases).

From the immune system: very rarely hypersensitivity reactions, incl. bronchospasm,

rash, swelling of the face and tongue, anaphylactic reactions, anaphylactoid reactions.

From the nervous system: often — headache, a feeling of unpleasant taste and smell.

From the side of the organ of vision: very rarely — glaucoma, increased intraocular pressure, cataract. A small number of spontaneous reports were associated with long-term drug therapy.

From the respiratory system: very often epistaxis; often — dryness of the mucous membrane in the nasal cavity and pharynx, irritation of the mucous membrane in the nasal cavity and pharynx (these adverse reactions, as well as nosebleeds were observed with the use of other intranasal drugs); very rarely perforation of the nasal septum (reported when taking intranasal corticosteroids).

With the use of some intranasal GCS, systemic effects may develop, especially when administered in high doses for a long time.

Special instructions: For adults and children over 12 years of age:

Do not use Flixonase nasal spray for more than 3 months. If it is necessary to use the drug for more than 3 months, a doctor’s consultation is required.

For children from 4 to 12 years old: Do not use Flixonase nasal spray for more than 2 months. If it is necessary to use the drug for more than 2 months, a doctor’s consultation is required. With prolonged use, regular monitoring of the function of the adrenal cortex is necessary.

There are reports of the manifestation of systemic effects when using nasal corticosteroids, especially in high doses for a long time.

Potential systemic effects may include ItsenkoCushing syndrome, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and less commonly a range of psychological or behavioral effects, including psychomotor hyperactivity, sleep disturbances, anxiety, depression, or aggressiveness (especially in children) .

It is recommended that you stop taking the drug and consult your doctor if there is no improveme

nt within 4 days.

Flixonase, aqueous nasal spray contains benzalkonium chloride, which can cause bronchospasm.

Dosing regimen: To achieve the full therapeutic effect, the drug should be used regularly. The maximum therapeutic effect is manifested after 3-4 days of therapy.

Adults and children over 12 years old:

1st week: 2 injections into each nostril 1 time / day (200 mcg / day);

from the 2nd week to 3 months: 1 or 2 injections into each nostril 1 time / day (100200 mcg / day).

The maximum daily dose is 200 mcg / day ( more than 2 injections into each nostril).

Elderly patients are prescribed in the usual dose for adults.

Children aged 4 to 12:

1 injection into each nostril 1 time / day (100 mcg / day). Do not exceed the recommended dose (100 mcg / day). In children aged 4 to 12 years, the drug should be used for the shortest possible period of time necessary to achieve control over the symptoms of the disease.

The maximum daily dose is 100 mcg (no more than 1 injection and each nostril).

Storage method: Keep out of the reach of children at a temperature not exceeding 25 degrees.

Packaging: The cardboard box contains a spray bottle, paper instructions.