Isoprinosine - 500 mg 8 Tablets

A drug with immunostimulatory activity and non-specific antiviral action.

Trade name: Isoprinosine (Isoprinosine)

Compound: Each tablet contains:

Inosine pranobex 500 mg

* Auxiliary components: mannitol, wheat starch, povidone, magnesium stearate.

* Properties: Isoprinosine is a synthetic complex derivative of purine with immunostimulating activity and nonspecific antiviral activity. It restores the functions of lymphocytes under conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helpers, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killers, the function of T-suppressors and T-helpers, increases the production of IgG, interferon gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines — IL-4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and measles virus, human T-cell lymphoma virus type III, polioviruses, influenza A and B, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis. The mechanism of the antiviral action of Isoprinosine is associated with the inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of some viruses. It enhances the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of viral RNA biosynthesis and translation of viral proteins, increases the production of alpha and gamma interferons by lymphocytes, which have antiviral properties.

With a combined appointment, it enhances the effect of interferon alfa, antiviral agents acyclovir and zidovudine.

* Indications: — treatment of influenza and other acute respiratory viral infections

— infections caused by Herpes simplex virus types 1, 2, 3 and 4:

— genital and labial herpes, herpetic keratitis

— herpes zoster, chicken pox

— infectious mononucleosis caused by the Epstein-Barr virus

— cytomegalovirus infection

— severe measles

papillomavirus infection: papillomas of the larynx / vocal cords (fibrous type), papillomavirus infection of the genitals in men and women, warts;

— molluscum contagiosum.

* Dosage and administration: Tablets are taken after meals with a small amount of water.

The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses (for adults — 6-8 tablets / day, for children — 1/2 tablet per 5 kg of body weight / day).

In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg body weight / day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children — 50 mg / kg / day.

The duration of treatment for acute diseases in adults and children is usually from 5 to 14 days. Treatment should be continued until the disappearance of clinical symptoms and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

* Contraindications: — urolithiasis disease

— gout

— arrhythmias

— chronic renal failure

* Precautionary measures: After 2 weeks of using Isoprinosine, it is recommended to monitor the content of uric acid in the blood serum and in the urine.

With long-term use after 4 weeks of use, it is advisable to monitor liver and kidney function every month (transaminase activity in blood plasma, creatinine, uric acid levels).

* Side effects: From the gastrointestinal tract: often — nausea, vomiting, epigastric pain; sometimes — diarrhea, constipation.

From the side of the liver and biliary tract: often — a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

Dermatological reactions: often — itching.

From the nervous system: often — headache, dizziness, weakness; sometimes — drowsiness, insomnia.

* Storage method: Store at a temperature not exceeding 30 degrees.

* Package: Cardboard box contains 8 tablets, paper instructions.