Xithrone - 500 mg 5 Tablets

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

— infections of the upper respiratory tract and ENT organs: pharyngitis, tonsillitis, sinusitis, otitis media

— infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis, pneumonia, incl. caused by atypical pathogens

— infections of the skin and soft tissues: acne vulgaris of moderate severity, erysipelas, impetigo, secondarily infected dermatoses

— the initial stage of Lyme disease (borreliosis)

— migrating erythema (erythema migrans)

— urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis)

Tradename:

Xithrone

* Compound: Each tablet contains:

Azithromycin 500 mg

* Auxiliary components: Methyl cellulose, magnesium stearate, talc, croscarmellose sodium, sodium steryl fumerate.

* Properties: A broad-spectrum antibacterial drug from the group of azalide macrolides, acts bacteriostatically. By binding to the 50S subunit of ribosomes, it inhibits the peptide translocase at the translation stage, inhibits protein synthesis, slows down the growth and reproduction of bacteria, and in high concentrations has a bactericidal effect. It acts on extra- and intracellularly located pathogens. Microorganisms may be inherently resistant to the antibiotic or may become resistant to it.

* Method of application and dose: Azithromycin is taken orally 1 time / day, 500 mg, regardless of the meal.

Adults (including the elderly) and children over 12 years of age weighing over 45 kg.

For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues: 500 mg 1 time / day for 3 days (course dose - 1.5 g).

With erythema migrans: on the first day, 2 tab. 500 mg, then from the 2nd to the 5th day, 500 mg daily. Heading dose 3.0 g. In urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis): at the same time 2 tab. 500 mg.

* Contraindications: - severe hepatic and / or renal failure;

- children age up to 12 years with a body weight of less than 45 kg (for this dosage form);

- breast-feeding;

- simultaneous reception with ergotamine and dihydroergotamine;

- hypersensitivity to macrolide antibiotics.

Carefully:

- moderate violations of the liver and kidneys;

- with arrhythmias or a predisposition to arrhythmias and prolongation of the QT interval;

- with the combined use of terfenadine, warfarin, digoxin.

* Precautionary measures: If an antibiotic is missed, the missed dose should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours. After discontinuation of azithromycin therapy, hypersensitivity reactions in some patients may persist for a long time and may require specific therapy under medical supervision.

Influence on the ability to drive vehicles and control mechanisms: Given the likelihood of side effects from the central nervous system, care should be taken when driving vehicles and working with mechanisms.

* Side effects: From the digestive system: nausea, vomiting, diarrhea, abdominal pain, loose stools, flatulence, indigestion, anorexia, constipation, discoloration of the tongue, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver failure, liver necrosis (possibly fatal).

Allergic reactions: itching, skin rashes, angioedema, urticaria, photosensitivity, anaphylactic reaction (in rare cases fatal), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

From the side of the cardiovascular system: palpitations, arrhythmia, ventricular tachycardia, an increase in the QT interval, bidirectional ventricular tachycardia.

From the nervous system: dizziness / vertigo, headache, convulsions, drowsiness, paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.

From the senses: tinnitus, reversible hearing loss up to deafness (when taking high doses for a long time), impaired perception of taste and smell.

From the circulatory and lymphatic systems: thrombocytopenia, neutropenia, eosinophilia.

From the musculoskeletal system: arthralgia.

From the genitourinary system: interstitial nephritis, acute renal failure.

Others: vaginitis, candidiasis.

* Storage method: At a temperature not higher than 25 degrees. In a dry place.

* Package: The cardboard box contains 1, 2 or 3 blisters of 3 or 5 tablets.

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